Karl Romanowicz, our Principal Scientist, presented on his recently published work in Science Advances, where he and colleagues developed large-scale synthetic gene libraries and applied broad mutational scanning to decode variant effects in dihydrofolate reductase (DHFR), revealing how sequence variation drives antibiotic resistance across the protein family.

Central to the themes explored were the fundamental advantages that Broad Mutational Scanning brings to the table in biological discovery. If you’d like to learn more about how BMS can help advance your discovery hit rate, please contact us at SynPlexity today!